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Published on: September 14, 2010
Behcet's disease associated with malignancy in Korea: a single center experience
Joong Kyong Ahn1, Ji Min Oh, Jaejoon Lee
1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 IIwon-Dong, Gangnam-Gu, Seoul, 135-710, South Korea.
Rheumatology International
|December 18, 2009
Summary
Behcet
Area of Science:
- Rheumatology
- Oncology
- Epidemiology
Background:
- Behcet's disease (BD) is a rare multisystem inflammatory disorder.
- The association between BD and malignancy requires further investigation.
Purpose of the Study:
- To investigate the clinical characteristics of Behcet's disease patients who develop cancer.
- To identify the types of malignancies associated with BD in Korea.
Main Methods:
- Retrospective analysis of 1,769 Behcet's disease patients.
- Identification of 32 patients (1.8%) who developed cancer.
- Comparison of clinical characteristics between BD patients with and without malignancy.
Main Results:
- Myelodysplastic syndrome (MDS) and thyroid cancer were the most common malignancies.
- Malignancy was diagnosed before, at the same time, or after BD diagnosis in 31.3% of cases.
- Intestinal involvement was more frequent in BD patients with malignancy, though not statistically significant.
Conclusions:
- MDS and thyroid cancer are the most frequently associated cancers with Behcet's disease in Korea.
- Further research is needed to understand the pathogenic link between BD and cancer.
- The prevalence of malignancy in BD patients warrants continued study.
