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The role of PSA-NCAM in adult neurogenesis

Eduardo Gascon1, Laszlo Vutskits, Jozsef Zoltan Kiss

  • 1Developmental Biology Institute of Marseilles-Luminy (IBDML), Case 907, Parc Scientifique de Luminy, 13288 Marseille Cedex 9, France.

Advances in Experimental Medicine and Biology
|December 18, 2009
PubMed
Abstract

No abstract available in PubMed .

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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