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Updated: Jun 17, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Small cell carcinoma of the urinary bladder
Mukta Pant-Purohit1, Antonio Lopez-Beltran, Rodolfo Montironi
1Department of Hematology and Oncology and Pathology, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA.
Histology and Histopathology
|December 18, 2009
Summary
Small cell carcinoma of the urinary bladder (SCCUB) is a rare, aggressive cancer. This review covers SCCUB epidemiology, pathogenesis, and management, including new targeted therapies for neuroendocrine tumors.
Area of Science:
- Urology
- Oncology
- Genetics
Background:
- Small cell carcinoma of the urinary bladder (SCCUB) is a rare and aggressive neuroendocrine tumor.
- It predominantly affects males and is associated with risk factors like smoking and chronic bladder inflammation.
- SCCUB has a poor prognosis due to high metastatic potential and often asymptomatic early stages.
Purpose of the Study:
- To provide a comprehensive overview of SCCUB.
- To discuss the epidemiology, molecular pathogenesis, and histochemistry of SCCUB.
- To review current management strategies and advancements in targeted molecular therapy.
Main Methods:
- Literature review of epidemiology, molecular pathogenesis, histochemistry, and treatment of SCCUB.
- Analysis of recent studies on targeted molecular therapies for neuroendocrine tumors.
- Synthesis of current management options, including surgery, chemotherapy, and radiation therapy.
Main Results:
- SCCUB pathogenesis involves genetic material loss, tumor suppressor hypermethylation, and oncogene amplification.
- Standard treatment includes local resection with platinum-based chemotherapy, with radiation as an alternative or palliative measure.
- Recent advancements focus on targeted molecular therapies for neuroendocrine tumors.
Conclusions:
- SCCUB remains a challenging diagnosis with a poor prognosis.
- Multidisciplinary management is crucial for optimal patient outcomes.
- Emerging targeted therapies offer potential for improved treatment efficacy in neuroendocrine tumors.
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