Related Experiment Video
Updated: Jun 17, 2026

In Vitro Investigation of the Effects of the Hyaluronan-Rich Extracellular Matrix on Neural Crest Cell Migration
Published on: February 10, 2023
[Regulation of progenitor cell function by hyaluronidase]
Abstract:
This study demonstrated the possibility of in vivo activation of progenitor cells by hyaluronidase. Specifically, treatment with hyaluronidase increased the number of mesenchymal and bone marrow precursor cells, their proliferative activity, and differentiation. Also, it promoted stem cell mobilization into blood under effect of granulocyte colony-stimulating factor (G-CSF) and enhanced progenitor cell adhesive properties. Therapeutic efficiency of transplantation of mononuclear cells isolated from peripheral blood after administration of G-CSF improved under effect of hyaluronidase. Hyaluronidase immobilized by electron beam synthesis nanotechnology exhibited high specific activity with respect to stem cells via both enteral and parenteral routes.
Related Concept Videos
Regulation of Hematopoietic Stem Cells
Multipotency of Hematopoietic Stem Cells
Hematopoiesis
Differentiation of Common Myeloid Progenitor Cells
Maintenance of the ES Cell State
Regulation of Angiogenesis and Blood Supply

