Reaction of the Blood System of ICR Mice with Traumatic Brain Injury

We studied changes in the blood system of ICR mice following traumatic brain injury (TBI). It was found that, along with neuroinflammation, TBI also causes bone marrow hyperplasia and leukocytosis by inducing the formation of additional centers of granulocytic hematopoiesis (hematopoietic islands) and the activation of granulocyte progenitor cells. These results support the hypothesis that neuroinflammation in TBI is dependent on bone marrow hematopoiesis and the mobilization of immune cells and blood cells from the bone marrow to the blood. They also suggest that the bone marrow may be a potential therapeutic target in the treatment of neuroinflammation.