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Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
Published on: September 20, 2016
Wrestling with native chemical ligation
Hagan Bayley1, Stephen Cheley, Leon Harrington
1Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom. hagan.bayley@chem.ox.ac.uk
ACS Chemical Biology
|December 19, 2009
Abstract:
An improved method for the semisynthesis of a potassium channel involving native chemical ligation allows the introduction of short sequences containing non-canonical amino acids at any position within the polypeptide chain. The work enhances the technology available for a range of fundamental investigations of membrane proteins and for applications of membrane channels and pores in biotechnology.
