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Related Concept Videos

Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...

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Capillary Force Lithography for Cardiac Tissue Engineering
10:09

Capillary Force Lithography for Cardiac Tissue Engineering

Published on: June 10, 2014

Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs.

Deok-Ho Kim1, Elizabeth A Lipke, Pilnam Kim

  • 1Department of Biomedical Engineering and Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

Proceedings of the National Academy of Sciences of the United States of America
|December 19, 2009
PubMed
Summary

Researchers created a nanoscale model of heart tissue that mimics native structure. This model reveals how controlling nanoscale features influences cardiac function and offers insights for tissue repair.

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Last Updated: Jun 17, 2026

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10:09

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Published on: June 10, 2014

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing
11:09

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing

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Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells
10:37

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

Area of Science:

  • Biomaterials Science
  • Cardiac Physiology
  • Tissue Engineering

Background:

  • Cardiac tissue exhibits complex multi-scale structural organization.
  • Nanoscale control of cardiac function remains underexplored.
  • Understanding native tissue ultrastructure is key to biomimicry.

Purpose of the Study:

  • To develop a scalable, nanotopographically controlled model of myocardium.
  • To investigate the influence of nanoscale mechanical cues on cardiac function.
  • To explore the relationship between cell-material interactions and tissue-level physiology.

Main Methods:

  • Constructing myocardium models guided by nanoscale mechanical cues from hydrogels.
  • Analyzing anisotropic action potential propagation and contractility.
  • Assessing the sensitivity of cell geometry, conduction velocity, and cell-cell coupling protein expression to nanoscale substratum features.

Main Results:

  • Tissue constructs displayed anisotropic action potential propagation and contractility mimicking native tissue.
  • Cell geometry, action potential conduction velocity, and cell-cell coupling protein expression were highly sensitive to nanoscale substratum features.
  • Nanoscale control of cell-material interactions influenced tissue structure and function.

Conclusions:

  • Controlling cell-material interactions at the nanoscale can dictate tissue-level structure and function.
  • This approach provides novel insights into in vivo cardiac physiology.
  • The developed models offer potential materials for cardiac tissue repair.