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Adaptive response by state-dependent inactivation.

Tamar Friedlander¹, Naama Brenner

¹Departments of Physics, Laboratory of Network Biology Research, Technion - Israel Institute of Technology, Haifa 32000, Israel.

Proceedings of the National Academy of Sciences of the United States of America

|December 19, 2009

Summary

This summary is machine-generated.

Many biological channels and receptors adapt to stimuli by removing molecules from active pools. This study presents a unifying theory showing this process averages past activity and influences output, explaining diverse adaptive responses.

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Area of Science:

Biophysics
Systems Biology
Computational Neuroscience

Background:

Membrane channels and receptors show adaptive desensitization to sustained stimuli.
A common mechanism involves activity-dependent removal of molecules to an inactive pool.
This process has been studied in isolation across different biological systems.

Purpose of the Study:

To identify common principles underlying adaptive responses in biological systems.
To propose a unifying theoretical framework for desensitization mechanisms.
To distinguish universal features from system-specific adaptations.

Main Methods:

Theoretical analysis of a class of mathematical models.
Investigation of general kinetic properties.
Distinguishing universal and system-specific features.

Main Results:

Molecule availability encodes a temporal average of past activity.
This averaging feeds back multiplicatively onto the system's output.
Recovery kinetics from the inactive pool dictate the form of adaptive response.

Conclusions:

A general mechanism of activity-dependent molecule sequestration underlies diverse adaptive responses.
The theoretical framework unifies various system-specific adaptive behaviors (e.g., precise, input-dependent, exponential, power-law).
This work provides insights into the fundamental principles of biological adaptation and feedback regulation.