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[Renin and the heart]

Dilek Ural1, Metin Cetin

  • 1Department of Cardiology, Medicine Faculty of Kocaeli University, Kocaeli, Turkey. dilekural@gmail.com

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|December 19, 2009
PubMed

Insights

Direct renin inhibitor aliskiren reduces plasma renin activity, a cardiovascular risk factor, offering a novel approach to managing hypertension and cardiovascular diseases beyond blood pressure reduction.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Context:

  • The renin-angiotensin system (RAS) is crucial in cardiovascular regulation.
  • RAS inhibition lowers blood pressure but can increase plasma renin activity, posing residual cardiovascular risk.
  • Existing treatments like ACE inhibitors and ARBs do not reduce plasma renin activity.

Purpose:

  • To highlight aliskiren as a direct renin inhibitor.
  • To differentiate aliskiren's mechanism from ACE inhibitors and ARBs.
  • To discuss aliskiren's potential in cardiovascular disease management.

Summary:

  • Aliskiren uniquely reduces plasma renin activity, an independent cardiovascular risk factor.
  • Unlike ACE inhibitors and ARBs, aliskiren addresses the negative feedback issue in RAS blockade.
  • Its efficacy and safety in hypertension are established, with ongoing research into its effects on cardiovascular mortality and morbidity.

Impact:

  • Aliskiren offers a new therapeutic option for RAS blockade.
  • It may mitigate residual cardiovascular risk associated with traditional RAS inhibitors.
  • Further research is investigating its comprehensive impact on cardiovascular outcomes.

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