Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 4, 2026

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
05:52

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model

Published on: December 8, 2023

Endothelin-Dependent Myocardial Dysfunction in an Experimental Endotoxic Shock Model.

Mustafa Boz1, Alper Bektaş İskit1

  • 1Department of Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, Türkiye.

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|July 3, 2026
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systemic Immune-Inflammatory Markers for Predicting Infarct Volume and Mortality in Patients with Acute Ischemic Stroke: A Retrospective Cohort Study.

Journal of clinical medicine·2026
Same author

Non-HLA Genetic Polymorphisms of Interleukin-17 and Interleukin-23 Receptor in Behcet's Syndrome.

Genetic testing and molecular biomarkers·2026
Same author

Colchicine has Dose-Dependent Therapeutic Effects in a LPS-Induced Experimental Endotoxemia Model.

Pharmacology research & perspectives·2026
Same author

Biosimilars and interchangeability: Regulatory, scientific, and global perspectives.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Knowledge and self-confidence of healthcare workers to perform transurethral catheterization: a matter deserving attention!

World journal of urology·2025
Same author

What Do Patients Seek Care for at a Health Facility in the Aftermath of an Earthquake? Experiences From an Emergency Medical Team in Türkoğlu, Türkiye 2023.

Disaster medicine and public health preparedness·2025

Endotoxemia impairs heart function by increasing endothelin, not nitric oxide. Blocking endothelin receptors improved cardiac contractility in this septic shock model.

Area of Science:

  • Cardiovascular Physiology
  • Septic Shock Pathophysiology
  • Endothelial Function

Background:

  • Septic shock frequently leads to cardiovascular failure due to impaired myocardial contractility.
  • The precise mechanisms underlying this cardiac dysfunction remain unclear.
  • Endothelin and nitric oxide (NO) pathways are implicated in cardiovascular regulation.

Purpose of the Study:

  • To investigate the roles of endothelin and nitric oxide in cardiac dysfunction during experimental endotoxic shock.
  • To evaluate the therapeutic potential of endothelin receptor antagonism and nitric oxide synthase inhibition.

Main Methods:

  • Endotoxic shock was induced in rats using lipopolysaccharide (LPS).
  • Isolated perfused hearts and cardiac muscle preparations were used to assess myocardial contractility.

More Related Videos

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

Related Experiment Videos

Last Updated: Jul 4, 2026

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
05:52

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model

Published on: December 8, 2023

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

  • The effects of tezosentan (endothelin receptor antagonist) and NOS inhibitors were evaluated.

    • Main Results:

    • LPS significantly reduced myocardial contractility in perfused hearts but not in isolated muscle preparations.
    • Tezosentan attenuated the LPS-induced decrease in contractility.
    • Nitric oxide synthase inhibitors did not affect myocardial contractility or coronary perfusion pressure.

    Conclusions:

    • Myocardial depression in endotoxic shock is dependent on an intact coronary vasculature.
    • Endothelin, released from the vascular endothelium, plays a critical role in myocardial dysfunction during endotoxic shock.
    • Nitric oxide has a limited role in this septic shock model.