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Systemic Immune-Inflammatory Markers for Predicting Infarct Volume and Mortality in Patients with Acute Ischemic
Selim Degirmenci1, Erhan Arikan1, Mustafa Boz1
1Department of Emergency Medicine, Faculty of Medicine, Bilecik Şeyh Edebali University, Bilecik 11230, Türkiye.
Journal of Clinical Medicine
|June 26, 2026
Summary
The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) may help identify high-risk acute ischemic stroke (AIS) patients early. Higher SII and SIRI scores correlated with increased mortality in AIS patients.
Area of Science:
- Neurology
- Biomarkers
- Inflammation
Background:
- Acute ischemic stroke (AIS) requires rapid prognostic biomarkers beyond standard assessments.
- Existing methods like neurological exams and imaging have limitations in predicting outcomes and infarct volume.
- There is a need for accessible laboratory-based markers for early risk stratification in AIS.
Purpose of the Study:
- To investigate the prognostic value of the systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) in AIS patients.
- To determine if SII and SIRI scores can predict infarct volume and mortality in AIS.
- To assess the utility of these inflammatory markers in emergency department settings for AIS management.
Main Methods:
- Retrospective analysis of 257 AIS patients admitted to Bilecik Training and Research Hospital.
- Exclusion of patients transferred for reperfusion therapy due to unavailability of treatments.
- Calculation of SII and SIRI scores from complete blood count data; infarct volume assessed via MRI; mortality data collected over 2 years.
Main Results:
- Higher SII and SIRI scores were significantly associated with increased all-cause mortality at 1 month, 1 year, and 2 years post-AIS.
- No significant difference in infarct volume was noted between high and low SII/SIRI groups.
- The study analyzed 257 AIS patients, with a median age of 76, and found 2-year mortality rates up to 29.6%.
Conclusions:
- SII and SIRI scores, derived from routine blood tests, show potential as early prognostic biomarkers in AIS.
- These indices may aid in identifying high-risk AIS patients for closer monitoring and management.
- Further prospective studies are warranted to validate the role of SII and SIRI in clinical practice for acute stroke care.
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