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Related Experiment Video

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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

Exploring disease through metabolomics.

Nawaporn Vinayavekhin1, Edwin A Homan, Alan Saghatelian

  • 1Harvard University, 12 Oxford St., Cambridge, Massachusetts 02138, USA.

ACS Chemical Biology
|December 22, 2009
PubMed
Summary
This summary is machine-generated.

Metabolomics analyzes metabolite changes in biological samples. This review highlights how advanced metabolomics techniques enhance understanding of cellular processes and disease pathways in various research fields.

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Last Updated: Jun 17, 2026

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A Strategy for Sensitive, Large Scale Quantitative Metabolomics
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A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

Area of Science:

  • Biomedical Research
  • Clinical Sciences
  • Basic Sciences

Background:

  • Metabolomics involves analyzing changing metabolite levels in biological samples.
  • Recent technical advancements have significantly expanded metabolomics applications.
  • Improvements in instrumentation, data analysis, and databases have accelerated metabolite measurement and identification.

Purpose of the Study:

  • To review the integration of metabolomics in basic and biomedical research.
  • To highlight how metabolomics enriches understanding of cellular and physiological biology.
  • To focus on pathways linked to disease and small molecule regulation.

Main Methods:

  • Review of current metabolomics approaches and their applications.
  • Analysis of technical advancements in instrumentation and data processing.
  • Integration of metabolomics data with other profiling methods (genomics, proteomics).

Main Results:

  • Metabolomics provides unique insights into small molecule regulation and signaling.
  • Applications include biomarker discovery and mechanistic studies of metabolic pathways.
  • Significant enrichment of understanding in cellular and physiological biology, particularly in disease contexts.

Conclusions:

  • Metabolomics is a powerful tool for biological and biomedical research.
  • It offers complementary insights to genomics and proteomics.
  • Further integration of metabolomics will advance disease mechanism understanding.