Next generation biodegradable ureteral stent in a yucatan pig model

Area of Science:

• Biomaterials Science
• Urology
• Medical Devices

Background:

• Ureteral stents are crucial for kidney drainage but cause symptoms and require removal.
• Previous biodegradable stents had issues with biocompatibility and degradation.
• First-generation biodegradable stents degraded by 10 weeks and needed a sheath for placement.

Purpose of the Study:

• To report on second and third-generation biodegradable ureteral stents (Uriprene).
• To evaluate their rapid degradation and ease of placement.
• To assess their biocompatibility and efficacy in facilitating kidney drainage.

Main Methods:

• Two groups of Yucatan pigs were stented with control biostable or second-generation Uriprene stents.
• Renal function, hydronephrosis, and stent degradation were monitored via ultrasound and urography.
• Third-generation stents were implanted in Yorkshire pigs to assess degradation and function.

Main Results:

• Second-generation Uriprene stents degraded within 10 weeks; third-generation stents degraded within 4 weeks.
• Uriprene stents showed less hydronephrosis and reduced ureteral inflammation compared to biostable stents.
• Uriprene stents demonstrated high tensile and coil strength, comparable to commercial plastic stents.

Conclusions:

• Uriprene biodegradable ureteral stents are biocompatible and ensure effective renal drainage.
• These stents significantly reduce the need for secondary removal procedures.
• They hold promise for minimizing stent-related morbidity, including infection and irritative symptoms.