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Pulmonary amyloidosis mimicking multiple metastatic lesions on F-18 FDG PET/CT
Ji Hyoung Seo1, Sang Woo Lee, Byeong-Cheol Ahn
1Department of Nuclear Medicine, Kyungpook National University Hospital, 50, Jung-gu, Daegu, 700-721, Republic of Korea. seonoopy@medimail.co.kr
Abstract:
We report a case of amyloid pulmonary nodules with positive FDG uptake that mimic multiple lung metastases. A 54-year-old female patient was referred for the evaluation of multiple lung nodules. A PET/CT scan revealed mild FDG uptake in various sized pulmonary nodules. Resected nodules contained amorphous eosinophilic proteineous material with focal calcification, consistent with amyloidosis. Pulmonary amyloidosis should be added to the differential diagnosis for cases of multiple pulmonary nodules that show positive FDG uptake.
Insights
Pulmonary amyloidosis can present as multiple lung nodules with positive FDG uptake on PET/CT scans. This condition mimics lung metastases, highlighting the need for careful differential diagnosis.
Area of Science:
- Pulmonology
- Pathology
- Nuclear Medicine
Background:
- Amyloidosis is a rare condition characterized by the buildup of abnormal proteins in organs.
- Pulmonary involvement can manifest in various forms, including nodules.
Observation:
- A 54-year-old female presented with multiple pulmonary nodules detected on imaging.
- Positron Emission Tomography/Computed Tomography (PET/CT) revealed mild Fluorodeoxyglucose (FDG) uptake in these nodules.
Findings:
- Histopathological examination of resected nodules showed amorphous, eosinophilic, proteinaceous material with focal calcification.
- These findings were consistent with amyloid deposition, confirming pulmonary amyloidosis.
Implications:
- Pulmonary amyloidosis should be considered in the differential diagnosis of patients with multiple pulmonary nodules exhibiting positive FDG uptake.
- This case underscores the importance of integrating imaging findings with histopathology for accurate diagnosis.
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