Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Doxycycline release from cyclodextrin oligomer-containing collagen gels.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Identification of low threshold off-target activation pathways during stimulation of carotid baroreceptor afferents in swine.

Journal of neural engineering·2026
Same author

Prevalence of sympathetic fibers within the rat cervical vagus, and functional consequence on physiological effects mediated by vagus nerve stimulation (VNS).

Journal of neural engineering·2026
Same author

Computational modeling of human vagus nerve stimulation with three-dimensional fascicular morphology.

APL bioengineering·2026
Same author

Impact of infusion conditions and anesthesia on CSF tracer dynamics in mouse brain.

Fluids and barriers of the CNS·2026
Same author

Identification of low threshold off-target activation pathways during stimulation of carotid baroreceptor afferents in swine.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jun 17, 2026

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Cyclodextrin-based device coatings for affinity-based release of antibiotics.

Thimma R Thatiparti1, Andrew J Shoffstall, Horst A von Recum

  • 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave., Wickenden Room 220, Cleveland, OH 44106, USA.

Biomaterials
|December 22, 2009
PubMed
Summary

Cyclodextrin hydrogels offer tunable, robust networks for medical device coatings. These gels provide sustained antibiotic release and enhanced bactericidal activity, showing great potential as drug delivery platforms.

More Related Videos

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Related Experiment Videos

Last Updated: Jun 17, 2026

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Cyclodextrin-based hydrogels offer tunable mechanical properties.
  • These networks can serve as effective device coatings.
  • Drug loading and release characteristics are crucial for biomedical applications.

Purpose of the Study:

  • To synthesize and characterize robust cyclodextrin-based hydrogels.
  • To evaluate their potential as medical device coatings.
  • To investigate their drug loading and sustained release capabilities.

Main Methods:

  • Hydrogel synthesis and rheological property analysis.
  • Drug loading studies in various solvents and release kinetics.
  • Fourier-transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA).
  • Medical device coating and characterization using scanning electron microscopy (SEM).
  • Assessment of bactericidal activity against Staphylococcus aureus.

Main Results:

  • Cyclodextrin hydrogels exhibited high storage modulus, indicating elastic properties.
  • Gels successfully loaded and released antibiotics with varying hydrophilicity.
  • Drug release from cyclodextrin gels was sustained for over 200 hours via affinity-based mechanisms.
  • Uniform, thin coatings were achieved on medical devices, unlike dextran gels.
  • Enhanced and prolonged bactericidal activity was observed compared to dextran controls.

Conclusions:

  • Cyclodextrin-based hydrogels are robust, tunable materials suitable for medical device coatings.
  • Their affinity-based drug release mechanism enables sustained antibiotic delivery.
  • These hydrogels demonstrate significant potential as advanced drug delivery platforms with improved efficacy.