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Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Fluorescence and DNA-binding spectral studies of neodymium(III) complex containing 2,2'-bipyridine,
Mozhgan Khorasani-Motlagh1, Meissam Noroozifar, Sohaila Mirkazehi-Rigi
1Department of Chemistry, University of Sistan & Baluchestan, Zahedan, Iran. mkhorasani@chem.usb.ac.ir
Abstract:
The interaction of [Nd(bpy)(2)Cl(3)xOH(2)], where bipy is 2,2'-bipyridine, with DNA has been studied by absorption, emission, and viscosity measurements. [Nd(bpy)(2)Cl(3)xOH(2)] showed absorption decreasing in charge transfer band with increasing of DNA. The binding constant, K(b) has been determined by absorption measurement and found to be (1.5+/-0.1)x10(5)M(-1). The fluorescent of [Nd(bpy)(2)Cl(3)xOH(2)] has been investigated in detail. The interaction was also studied by fluorescence quenching technique. The results of fluorescence titration revealed that DNA had the strong ability to quenching the intrinsic fluorescence of Nd(III) complex at 327 nm. The binding site number n, apparent binding constant K(b) and the Stern-Volmer quenching constant K(SV) have been determined. Thermodynamic parameters have been calculated according to relevant fluorescent data and Van't Hoff equation. Characterization of bonding mode has been studied. The results suggested that the major interaction mode between [Nd(bpy)(2)Cl(3)xOH(2)] and DNA was groove binding.
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