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Advances and perspectives in aptamer arrays.
William Rowe1, Mark Platt, Philip J R Day
1Manchester Interdisciplinary Biocentre, The University of Manchester, UK.
Integrative Biology : Quantitative Biosciences From Nano to Macro
|December 22, 2009
Summary
Aptamer arrays offer antibody-like binding for molecular diagnostics and metabolite analysis. Recent innovations advance multiplexed aptamer arrays for quantitative biological system analysis.
Area of Science:
- Biochemistry
- Molecular Biology
- Analytical Chemistry
Background:
- Aptamers are oligonucleotide-based molecules with high affinity for specific targets, comparable to antibodies.
- Multiplexed aptamer arrays have been proposed for quantifying thousands of proteins in biological samples like blood and urine.
- Tagless aptamer detection enables analysis of small molecules and metabolites.
Purpose of the Study:
- To review existing technologies for aptamer array development.
- To highlight recent innovations in aptamer array technology.
- To discuss the potential for highly multi-parallelized arrays in biological system analysis.
Main Methods:
- Review of current aptamer array technologies.
- Analysis of recent technological advancements in the field.
- Discussion of potential applications in molecular diagnostics and metabolite profiling.
Main Results:
- Aptamers provide a versatile platform for molecular and metabolite detection.
- Innovations are enhancing the capabilities of aptamer arrays.
- The field is moving towards highly multiplexed quantitative analysis.
Conclusions:
- Aptamer arrays are a promising technology for advanced molecular diagnostics.
- Further innovations will facilitate comprehensive quantitative analysis of biological systems.
- The potential for metabolite-level bioanalyses using aptamer arrays is significant.
