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Multimodal cell imaging by ruthenium polypyridyl labelled cell penetrating peptides
Lynda Cosgrave1, Marc Devocelle, Robert J Forster
1National Bioimaging Platform, National Centre for Sensor Research, The School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
Chemical Communications (Cambridge, England)
|December 22, 2009
Abstract:
The capacity of ruthenium polypyridyl complexes as probes for combined confocal luminescence and resonance Raman imaging, enabled by their large Stokes shift, is demonstrated for a novel membrane sensitive Ru(ii) polypyridyl peptide. Confocal luminescence and resonance Raman imaging provides complementary information about the membrane phospholipid regions of the cell and the location of the dye within the cell.
