Prediction of potential protein post-translational modifications of the thioredoxin-1 molecule

V Wiwanitkit1

  • 1Wiwanitkit House, Bangkhae, Bangkok Thailand. wviroj@yahoo.com

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Protein Modifications in the RER

Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal sequences.
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

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These groups modify specific amino acids in a protein.
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Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
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Bacterial Protein Maturation

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Regulation of the Unfolded Protein Response

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Riboswitches01:56

Riboswitches

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The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...