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Updated: Jun 17, 2026
06:31
Identification and Dissection of Diverse Mouse Adipose Depots
Published on: July 11, 2019
The development and endocrine functions of adipose tissue
Sylvia P Poulos1, Dorothy B Hausman, Gary J Hausman
1The Coca-Cola Company, Research and Technology, Atlanta, GA 30313, United States. sypoulos@na.ko.com <sypoulos@na.ko.com>
Molecular and Cellular Endocrinology
|December 23, 2009
Summary
White adipose tissue, once viewed as simple fat storage, is now understood as a vital endocrine organ. Its secretions, adipokines, significantly impact metabolism, vascular, and immune systems, influencing various diseases.
Area of Science:
- Endocrinology
- Metabolic Science
- Cell Biology
Background:
- White adipose tissue (WAT) originates as fetal mesenchymal tissue.
- Traditionally recognized for energy storage, WAT is now established as a key endocrine organ.
- WAT secretions influence vascular, immune, and metabolic systems.
Purpose of the Study:
- To highlight the evolving understanding of white adipose tissue.
- To emphasize the endocrine functions of adipose tissue and its secreted factors (adipokines).
- To underscore the role of adipose tissue dysregulation in metabolic and cardiovascular diseases.
Main Methods:
- Review of existing literature on adipose tissue development and function.
- Analysis of studies linking nutrient/hormonal influences to adipose tissue.
- Evaluation of epidemiological and intervention studies on adipose tissue and disease states.
Main Results:
- Adipose tissue secretions (adipokines) impact multiple physiological systems.
- Nutrient and hormonal factors significantly modulate adipose tissue development.
- Adipose tissue dysregulation is strongly associated with insulin resistance and cardiovascular disease.
Conclusions:
- Adipose tissue plays a critical role in systemic health beyond energy storage.
- Further research into adipokines and cell interactions will deepen our understanding of this endocrine organ.
- Adipose tissue's complex functions are integral to various pathologies and biological systems.
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