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HER2 codon 655 polymorphism is associated with advanced uterine cervical carcinoma
Łukasz Kruszyna1, Margarita Lianeri, Andrzej Roszak
1Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, 6 SwiecickiegoSt., 60-781 Poznań, Poland.
Clinical Biochemistry
|December 23, 2009
Summary
The HER2 655Val variant may be linked to advanced cervical cancer incidence. This finding suggests a potential genetic marker for cervical cancer risk in certain populations.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Overexpression of Human Epidermal growth factor Receptor 2 (HER2) in advanced cervical tumors is a potential indicator of poor patient outcomes.
- Genetic variations in HER2 may influence cancer development and progression.
Purpose of the Study:
- To investigate the association between the HER2 Ile655Val polymorphism (rs 1136201) and the risk of advanced cervical cancer.
- To determine if specific genotypes or alleles of HER2 are more prevalent in patients with advanced cervical cancer compared to controls.
Main Methods:
- Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLPs) was used to analyze HER2 genotypes and alleles.
- The study included 109 patients with advanced cervical cancer and 220 healthy controls.
Main Results:
- Patients with advanced cervical cancer showed a higher prevalence of the HER2 Val/Val homozygous genotype (OR=3.706, p=0.0459).
- The HER2 Val/Val or Val/Ile heterozygous state was associated with an increased risk of advanced cervical cancer (OR=1.778, p=0.0176).
- No significant association was found between HER2 Ile655Val polymorphism and specific cancer characteristics.
Conclusions:
- The HER2 655Val variant may be associated with the incidence of advanced cervical cancer.
- This genetic variant could potentially serve as a biomarker for cervical cancer risk assessment.
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