HER2 codon 655 polymorphism is associated with advanced uterine cervical carcinoma
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Updated: Jun 17, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Łukasz Kruszyna1, Margarita Lianeri, Andrzej Roszak
1Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, 6 SwiecickiegoSt., 60-781 Poznań, Poland.
Objectives:
It has been suggested that overexpression of HER2 in advanced cervical tumors can be considered an independent predictor of poor patient outcome.
Design And Methods:
Employing PCR-RFLPs, we examined the distribution of HER2 Ile655Val (rs 1136201) genotypes and alleles in patients with advanced cervical cancer (n=109) and controls (n=220).
Results:
Odds ratio (OR) for patients with advanced cervical cancer with the HER2 Val/Val homozygous or Val/Ile heterozygous state was 1.778 (95% CI=1.117-2.830, p=0.0176). We also observed an association of the HER2 Val/Val genotype with advanced cervical cancer in the patient group OR=3.706 (95% CI=1.061-12.950, p=0.0459). However, we did not find a significant association between the distribution of genotypes or alleles and cancer characteristics for the HER2 Ile655Val polymorphism.
Conclusions:
Our results indicate that the HER2 655Val variant may be associated with the incidence of advanced cervical cancer.
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