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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Risk of cardiovascular disease in HIV-infected patients

Satyajit Das1

  • 1HIV & GU Medicine, Coventry Community Health Services, Stoney Stanton Road, Coventry CV1 4FH, UK. satyajit.das@coventrypct.nhs.uk

The Journal of Antimicrobial Chemotherapy
|December 23, 2009
PubMed

Insights

Highly active antiretroviral therapy (HAART) has significantly increased HIV life expectancy. Long-term HIV management now requires addressing age-related conditions like cardiovascular disease (CVD).

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Gerontology

Background:

  • The advent of highly active antiretroviral therapy (HAART) has transformed HIV infection from a terminal illness into a chronic condition.
  • Increased life expectancy for people with HIV necessitates a shift in treatment focus towards long-term health management.
  • Age-associated comorbidities, particularly cardiovascular disease (CVD), are emerging as significant concerns in the aging HIV population.

Purpose of the Study:

  • To explore and discuss the evidence linking HIV infection to increased cardiovascular risk.
  • To examine the potential cardiovascular risks associated with antiretroviral therapy (ART).
  • To highlight the importance of managing age-related diseases in long-term HIV care.

Main Methods:

  • Literature review of studies investigating cardiovascular risk in HIV-infected individuals.
  • Analysis of data on the association between specific antiretroviral drugs and cardiovascular events.
  • Synthesis of current understanding regarding HIV-related inflammation and its impact on cardiovascular health.

Main Results:

  • Evidence suggests that HIV infection itself is an independent risk factor for cardiovascular disease.
  • Certain antiretroviral therapies may be associated with an elevated risk of cardiovascular complications.
  • The interplay between HIV, aging, and traditional cardiovascular risk factors requires careful consideration.

Conclusions:

  • Long-term management of HIV must prioritize the prevention and treatment of cardiovascular disease.
  • Further research is needed to fully elucidate the mechanisms of cardiovascular risk in HIV and to optimize ART regimens for cardiovascular safety.
  • A comprehensive approach integrating infectious disease and cardiovascular care is essential for improving outcomes in aging individuals with HIV.

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