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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Updated: Jun 17, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

HLA and kidney transplantation.

B Clark¹, D J Unsworth

¹St James's University Hospital, Leeds, UK.

Journal of Clinical Pathology

|December 23, 2009

Summary

Human Leukocyte Antigen (HLA) matching remains crucial in kidney transplantation, significantly improving graft survival rates and influencing patient outcomes. Understanding immunogenetics and immunosuppression strategies is key for successful transplants.

Area of Science:

Immunogenetics
Transplantation immunology

Background:

Kidney transplantation involves complex immune responses.
Rejection and immunosuppression are critical factors in graft success.

Purpose of the Study:

To review the role of immunogenetics in kidney transplantation.
To discuss immunology, rejection, and immunosuppression strategies.
To analyze the impact of HLA matching on graft survival.

Main Methods:

Literature review focusing on immunogenetics and transplantation outcomes.
Analysis of data correlating HLA matching with graft survival.
Discussion of different graft sources and their associated outcomes.

Main Results:

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Last Updated: Jun 17, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

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Published on: September 6, 2017

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Human Leukocyte Antigen (HLA) matching continues to impact kidney transplant outcomes.

Improved HLA matching correlates with enhanced graft survival.

Graft source influences transplant success rates.

Conclusions:

HLA matching is a vital component for optimizing kidney transplant success.
Further research into immunogenetic factors and immunosuppression is warranted.
Consideration of graft source is essential for predicting transplant outcomes.