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Updated: Jun 17, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
A method for improving the efficiency of therapy for melanoma
R G Nikitina1, V P Mardynskaja, T G Morozova
1Medical Radiology Center, Russian Academy of Medical Sciences, Obninsk, Russia. roza@mrrc.obninsk.ru
Abstract:
A method for photodynamic therapy was developed in experiments on the model of melanoma B16. The photosensitizer is injected by two doses, while laser exposure is carried out during coincidence of its maximum accumulation phases in tumor vessels and cells. This method increased the percentage of animals with complete regression of the tumor, decreased the coefficient of absolute tumor increase in animals with progressive tumor growth, increased survival of mice, and significantly decreased melanoma metastasizing to the lungs in comparison with untreated animals and even with the standard photodynamic therapy.
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