Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dermatomyositis with Anti-MDA5 Autoantibodies After SARS-CoV-2 mRNA Vaccination Treated with Tofacitinib: Integrating Literature Evidence and a Novel Observation.

Antibodies (Basel, Switzerland)·2026
Same author

Factors Associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA): Real-World Evidence from a Single-Center Cross-Sectional Study.

Journal of personalized medicine·2026
Same author

The Impact of PRAC EMA/AIFA Recommendations on the Prescriptions of JAKi and b-DMARDs: Preliminary Results of the Survey from 21 Rheumatological Italian Centers Affiliated with CReI.

Journal of personalized medicine·2026
Same author

Ixekizumab for the treatment of psoriatic arthritis: an Italian multicentric retrospective observational study.

Scientific reports·2026
Same author

Biopsy-Driven Synovial Pathophenotyping in RA: A New Approach to Personalized Treatment.

Journal of personalized medicine·2025
Same author

Let's trace: Leishmaniasis in Tuscany (Italy), tracking, research, analysis and continuous evaluation - a retrospective study protocol on underreporting of human cases, geolocation and public health implications.

BMJ open·2025
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2026

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

[Environmental factors and autoimmunity].

Mariangela Manfredi, Maurizio Benucci

    Recenti Progressi in Medicina
    |December 25, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Environmental factors significantly influence autoimmune disease development. This study explores UVB exposure, vitamin D activation, air pollutants, and smoking

    More Related Videos

    Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
    04:39

    Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

    Published on: March 17, 2023

    Murine Bilateral Renal Lymphadenectomy
    06:31

    Murine Bilateral Renal Lymphadenectomy

    Published on: December 30, 2025

    Related Experiment Videos

    Last Updated: Jun 17, 2026

    Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
    06:19

    Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

    Published on: September 9, 2022

    Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
    04:39

    Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

    Published on: March 17, 2023

    Murine Bilateral Renal Lymphadenectomy
    06:31

    Murine Bilateral Renal Lymphadenectomy

    Published on: December 30, 2025

    Area of Science:

    • Immunology
    • Environmental Health
    • Dermatology

    Background:

    • Autoimmune diseases result from complex genetic and environmental interactions.
    • The major histocompatibility complex (MHC) is a key genetic risk factor.
    • Environmental triggers are increasingly recognized in disease pathogenesis.

    Discussion:

    • UVB radiation exposure and vitamin D activation's role in autoimmunity.
    • Impact of airborne toxic agents, particularly on occupational workers.
    • Cigarette smoking's contribution to rheumatoid arthritis and specific autoantibodies.

    Key Insights:

    • UVB exposure and vitamin D metabolism are linked to autoimmune development.
    • Occupational exposure to air pollutants may increase autoimmunity risk.
    • Smoking is associated with rheumatoid arthritis and autoantibody production.

    Outlook:

    • Further research into environmental factors influencing autoimmune diseases.
    • Investigating preventative strategies targeting environmental exposures.
    • Understanding the interplay between genetics and environment in autoimmunity.