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Related Experiment Video

Updated: Jun 17, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Vitronectin concentrations predict risk in patients undergoing coronary stenting.

Wolfgang Derer¹, Elliot S Barnathan, Erdal Safak

¹Berlin Buch, Franz-Volhard Klinik Berlin, Germany.

Circulation. Cardiovascular Interventions

|December 25, 2009

Summary

Elevated vitronectin levels in patients with acute coronary syndrome correlate with increased risk of major adverse cardiovascular events after stenting. This suggests vitronectin may be an independent predictor of poor outcomes in these patients.

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Last Updated: Jun 17, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Area of Science:

Cardiology
Biochemistry
Clinical Medicine

Background:

Vitronectin is a multifunctional protein involved in cell adhesion and protein interactions.
It interacts with various plasma and cell proteins, including the vitronectin receptor.
Abciximab, a drug used in acute coronary syndromes, binds to components sharing the beta(3) subunit with the vitronectin receptor.

Purpose of the Study:

To investigate the correlation between baseline vitronectin concentrations and adverse cardiovascular outcomes in patients with acute coronary syndrome undergoing stenting.
To determine if vitronectin is an independent predictor of major adverse cardiovascular events.

Main Methods:

Retrospective analysis of baseline serum samples (n=233) from the EPISTENT trial.
Patients were stratified into quartiles based on vitronectin concentration.
Major adverse cardiovascular events (death, myocardial infarction, urgent revascularization) were assessed at 30 days and 6 months.

Main Results:

Patients in the highest quartile of vitronectin concentration (>or=49.7 microg/mL) had a significantly higher incidence of major adverse cardiovascular events at 30 days (18.2% vs 5.6%) and 6 months (20.0% vs 6.2%) compared to those in lower quartiles.
In multivariate analysis, elevated baseline vitronectin remained an independent predictor of major adverse cardiovascular events at both 30 days and 6 months.
No interaction was observed between abciximab treatment and vitronectin levels.

Conclusions:

Vitronectin may serve as an independent predictor of adverse cardiovascular outcomes in patients undergoing acute stenting.
Higher vitronectin levels are associated with increased risk of major adverse cardiovascular events post-stenting.