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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: Jun 17, 2026

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
11:12

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

Correlation between WT1 expression and cell proliferation in endometrial cancer.

Satoshi Dohi1, Satoshi Ohno, Yumiko Ohno

  • 1Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa, 920-8641 Japan. satoshi-dohi@y6.dion.ne.jp

Anticancer Research
|December 25, 2009
PubMed
Summary

Wilms' tumor gene WT1 is overexpressed in endometrial cancer and linked to tumor progression. WT1 expression correlates with cell proliferation, suggesting a role in endometrial cancer development.

Related Experiment Videos

Last Updated: Jun 17, 2026

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
11:12

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The Wilms' tumor gene (WT1) is overexpressed in endometrial cancer.
  • WT1 is recognized as a prognostic factor, but its pathophysiological role, including cell proliferation, is not fully understood.

Purpose of the Study:

  • To investigate the role of WT1 in endometrial cancer.
  • To determine the correlation between WT1 expression and cell proliferation.

Main Methods:

  • Immunohistochemistry was used to analyze WT1 expression.
  • Proliferating cell nuclear antigen (PCNA) labeling index was assessed to measure cell proliferation.
  • The study included 70 patients with endometrial cancer.

Main Results:

  • WT1 expression was detected in 91% of cases.
  • WT1 expression correlated with advanced FIGO stage, myometrial invasion, and high-grade differentiation, indicating upregulation with tumor progression.
  • A significant positive correlation was found between PCNA labeling index and WT1 expression score (p=0.0081).

Conclusions:

  • WT1 expression is associated with tumor progression in endometrial cancer.
  • WT1 may play a role in regulating cell proliferation in endometrial cancer.