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Updated: Jun 17, 2026
09:29
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
Herpesviridae and novel inhibitors
George Siakallis1, Demetrios A Spandidos, George Sourvinos
1Department of Virology, Faculty of Medicine, University of Crete, Crete, Greece.
Antiviral Therapy
|December 25, 2009
Summary
Novel antiviral agents show promise for treating herpesvirus infections, addressing limitations of current therapies. This review highlights promising compounds nearing clinical trials and FDA approval for improved antiherpetic drug development.
Area of Science:
- Virology
- Medicinal Chemistry
- Pharmacology
Background:
- Herpesviridae is a large family of double-stranded DNA viruses infecting humans and animals.
- Eight human herpesviruses exist, including herpes simplex virus (HSV) types 1 and 2, and Epstein-Barr virus.
- Current antiviral therapies for herpesviruses have limited efficacy and significant toxicity.
Purpose of the Study:
- To review recent advancements in novel antiherpetic agents.
- To identify promising compounds for clinical trials and FDA approval.
- To explore diverse molecular mechanisms of action in antiviral therapy.
Main Methods:
- Literature review of recent data on novel antiherpetic agents.
- Focus on agents with proven efficacy against herpesviruses.
- Analysis of compounds progressing towards clinical trials and regulatory approval.
Main Results:
- Several novel classes of antiviral agents demonstrate significant antiherpetic activity.
- Identified agents represent potential candidates for advanced clinical development.
- Diverse mechanisms of action are being explored for enhanced antiviral strategies.
Conclusions:
- There is a high medical need for new, effective antiherpetic drugs.
- Novel antiviral agents offer promising therapeutic alternatives.
- The development of these agents broadens perspectives in antiviral chemotherapy.
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