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Related Experiment Video

Updated: Jun 17, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species

Published on: August 16, 2018

A new 2-(2-phenylethyl)chromone from Chinese eaglewood.

Hao-Fu Dai¹, Jun Liu, Yan-Bo Zeng

¹Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. hfdai2001@yahoo.com.cn

Molecules (Basel, Switzerland)

|December 25, 2009

Summary

Researchers isolated a novel compound, 5,6,7,8-tetrahydroxy-2-(3-hydroxy-4-methoxyphenethyl)-5,6,7,8-tetrahydro-4H-chromen-4-one, from Chinese eaglewood. This discovery expands our understanding of compounds derived from Aquilaria sinensis.

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Last Updated: Jun 17, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species

Published on: August 16, 2018

Area of Science:

Natural Product Chemistry
Phytochemistry
Organic Chemistry

Background:

Chinese eaglewood (Aquilaria sinensis) is a valuable source of aromatic compounds.
Chromone derivatives are known for diverse biological activities.
Previous research on Aquilaria species has identified various bioactive metabolites.

Purpose of the Study:

To isolate and characterize a new compound from Aquilaria sinensis.
To elucidate the chemical structure of the novel 2-(2-phenylethyl)chromone derivative.
To contribute to the phytochemical knowledge of Chinese eaglewood.

Main Methods:

Isolation of the target compound using chromatographic techniques.
Structure elucidation through comprehensive Mass Spectrometry (MS) analysis.
Nuclear Magnetic Resonance (NMR) spectroscopy for detailed structural determination.
Comparison of spectroscopic data with existing literature.

Main Results:

A new 2-(2-phenylethyl)chromone derivative, 5,6,7,8-tetrahydroxy-2-(3-hydroxy-4-methoxyphenethyl)-5,6,7,8-tetrahydro-4H-chromen-4-one (1), was successfully isolated.
The structure of compound 1 was unequivocally established using advanced spectroscopic methods.
The isolated compound represents a novel addition to the known constituents of Aquilaria sinensis.

Conclusions:

The study successfully identified and characterized a new chromone derivative from Chinese eaglewood.
The findings enhance the understanding of the complex chemical profile of Aquilaria sinensis.
This novel compound may serve as a lead for future pharmacological investigations.