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Published on: September 17, 2014
[Study on the preparation of sustained-release pellets containing active components from Gastrodia elata by fluid-bed
Yan-long Hong1, Xiao Lin, De-sheng Xu
1Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of TCM, Shanghai 201203, China. hfuir@163.com
Objective:
To study the formulation of sustained-release pellets containing active components from Gastrodia elata by coating in the fluid-bed.
Methods:
The sustained-release pellets were prepared with Eudragit RS 100. The formulation was optimized by the direct comparison. Then their properties were evaluated.
Results:
The pellets presented the perfect sphericity and narrow diameter distribution and the curve of their cumulative drug release was in accord with Higuchi equation.
Conclusion:
The pellets have sustained-release effect in 12 hours.
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