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Updated: Jun 17, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
Published on: September 20, 2011
[Preparation and drug release property of paclitaxel nanoparticles]
Tie-wei Wang1, Yan Wu, Ming-jun Li
1National Center for Nanoscience and Technology, Beijing 100190, China. tieweiwang123@126.com
Objective:
To prepare paclitaxel nanoparticles and evaluate its drug release property in vitro.
Methods:
The chitosan-poly (lactide) copolymers were synthesized by ring-opening polymerization. Paclitaxel nanoparticles were prepared by the nanoprecipitation method. The encapsulation efficiency of the nanoparticles and the in vitro release of paclitaxel were studied.
Results:
The nanoparticles were fine and uniform spheres. The encapsulation efficiency of nanoparticles was up to 93.2%. The in vitro release profile showed the slow and stable release rate of paclitaxel.
Conclusion:
This method is simple and the nanoparticles possess good physical performance as sustained release character in vitro.
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