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Updated: Jun 17, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
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Microscopic diffusion tensor imaging of the mouse brain.

Yi Jiang1, G Allan Johnson

  • 1Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC 27710, USA.

Neuroimage
|December 26, 2009
PubMed
Summary
This summary is machine-generated.

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Researchers developed a high-resolution diffusion tensor imaging (DTI) protocol for the intact adult mouse brain. This robust method enables detailed quantitative study of white matter architecture and brain integrity.

Area of Science:

  • Neuroimaging
  • Mouse Brain Anatomy
  • Diffusion Tensor Imaging

Background:

  • Studying mouse brain white matter architecture requires high-resolution imaging techniques.
  • Existing diffusion tensor imaging (DTI) protocols may lack the necessary resolution or standardization for detailed analysis.

Purpose of the Study:

  • To establish a streamlined and robust protocol for acquiring high-resolution DTI data of the intact adult mouse brain.
  • To enable quantitative analysis of mouse brain integrity and white matter architecture at unprecedented spatial resolution.

Main Methods:

  • Acquisition of DTI data at 43 µm isotropic resolution over a 28-hour scan time.
  • Implementation of a protocol including specimen fixation, staining, image acquisition, reconstruction, post-processing, and distribution.

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Related Experiment Videos

Last Updated: Jun 17, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Diffusion Imaging in the Rat Cervical Spinal Cord
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Published on: April 7, 2015

  • Derivation of diffusion parameters (fractional anisotropy, axial/radial diffusivity) and fiber tracking.

    • Main Results:

    • Successful acquisition of high-resolution DTI data from the intact adult mouse brain.
    • Generation of key diffusion parameters and a color-coded orientation map.
    • Demonstration of fiber tracking for 3D connection information.

    Conclusions:

    • The developed DTI protocol provides a robust and repeatable method for high-resolution mouse brain imaging.
    • This protocol facilitates standardized, quantitative analysis of mouse brain white matter architecture.
    • The achieved spatial resolution represents a significant advancement in neuroimaging capabilities for mouse models.