Related Experiment Videos
Stability of miconazole in peritoneal dialysis fluid
1School of Pharmacy, University of Tasmania, Australia.
Abstract:
The stability of miconazole when mixed with peritoneal dialysis (PD) fluid and stored in plastic bags or glass ampuls was determined. Admixtures of miconazole and PD fluid were prepared in 2-L polyvinyl chloride (PVC) bags and in 1-mL glass ampuls to give a nominal initial concentration of 20 mg/mL. Duplicate samples of each solution were assayed in duplicate by high-performance liquid chromatography immediately after preparation and at various intervals up to nine days. All admixtures were stored in ambient light at 20 +/- 2 degrees C. A substantial loss of miconazole (greater than 10% of the initial concentration) occurred within four hours for admixtures stored in PVC bags, whereas similar solutions retained more than 90% of their initial miconazole concentration for at least three days when stored in glass ampuls under the same conditions. This suggests that the observed loss of miconazole from the PVC bags was largely due to an interaction with the container, rather than to chemical degradation in solution. About 28% of the miconazole lost from the solution during storage in PVC bags was recovered from the plastic by methanolic extraction. The rapid loss of miconazole when the drug was mixed with PD fluid and stored in PVC bags indicates that such admixtures should be prepared immediately before administration.
Insights
Miconazole stability is compromised in polyvinyl chloride (PVC) bags when mixed with peritoneal dialysis (PD) fluid, leading to rapid drug loss. Glass ampuls offer superior stability for miconazole PD admixtures.
Area of Science:
- Pharmaceutical Science
- Clinical Pharmacy
Background:
- Miconazole is an antifungal agent.
- Peritoneal dialysis (PD) is a treatment for kidney failure.
- The stability of drug admixtures in PD fluid is crucial for patient safety.
Purpose of the Study:
- To assess the stability of miconazole when mixed with PD fluid.
- To compare the stability of miconazole in polyvinyl chloride (PVC) bags versus glass ampuls.
Main Methods:
- Miconazole was mixed with PD fluid to a concentration of 20 mg/mL.
- Admixtures were stored in PVC bags and glass ampuls at 20°C.
- High-performance liquid chromatography (HPLC) was used to assay miconazole concentrations over nine days.
Main Results:
- Miconazole loss exceeded 10% within four hours in PVC bags.
- Over 90% of miconazole remained stable in glass ampuls for at least three days.
- Methanolic extraction recovered approximately 28% of the lost miconazole from PVC bags, indicating container interaction.
Conclusions:
- Miconazole is unstable in PD fluid when stored in PVC bags due to interaction with the plastic.
- Glass ampuls provide a more stable storage option for miconazole PD admixtures.
- Miconazole PD admixtures should be prepared immediately prior to administration when using PVC bags.