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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Myasthenia Gravis: Overview and Treatment

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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Related Experiment Video

Updated: Jun 17, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
05:55

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

Published on: December 1, 2023

[Monoclonal antibodies in multiple sclerosis].

Caroline Papeix1, Catherine Lubetzki

  • 1Fédération des maladies du système nerveux, groupe hospitalier Pitié-Salpêtrière, AP-HP, UPMC, Paris, France. caroline.papeix@psl.aphp.fr

Medecine Sciences : M/S
|December 29, 2009
PubMed
Summary

Multiple sclerosis (MS) treatments like Natalizumab show promise but carry risks. Evaluating the benefit-risk ratio of innovative MS therapies remains challenging for clinicians.

Area of Science:

  • Neuroimmunology
  • Neurology
  • Immunology

Context:

  • Multiple sclerosis (MS) is a leading cause of disability in young adults, characterized by inflammation, demyelination, and neurodegeneration.
  • Interferons and other immunomodulators have been used with limited success in managing MS.
  • Recent advancements include targeted therapies like Natalizumab, a monoclonal antibody.

Purpose:

  • To review the efficacy and safety of novel therapeutics for multiple sclerosis.
  • To highlight the challenges in assessing the benefit-risk ratio of advanced MS treatments.

Summary:

  • Natalizumab (Tysabri), targeting alpha-4 integrin, effectively reduces relapses and disease progression in relapsing MS by preventing immune cell migration to the brain.
  • Despite its efficacy, Natalizumab use is restricted due to severe side effects, including progressive multifocal leukoencephalopathy (PML).

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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

Related Experiment Videos

Last Updated: Jun 17, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
05:55

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

Published on: December 1, 2023

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
11:10

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

  • The case of Natalizumab underscores the complex risk-benefit analysis required for potent, innovative immunotherapies in MS.

    • Impact:

    • This analysis is crucial for clinicians managing MS patients with novel, highly effective treatments.
    • Understanding these trade-offs informs treatment decisions and patient selection for advanced MS therapies.
    • It emphasizes the ongoing need for careful monitoring and risk-benefit evaluation in MS therapeutics.