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Changes in the interrelationship between leptin, resistin and adiponectin in early neonatal life

Emanuela Marinoni1, Giovanna Corona, Francesca Ciardo

  • 1Centre for Scientific Research, San Pietro Hospital, Fatebenefratelli, Rome, Italy. emanuelamarinoni@hotmail.com

Frontiers in Bioscience (Elite Edition)
|December 29, 2009
PubMed

Insights

Fetal adipokine levels, including leptin, adiponectin, and resistin, are largely independent of maternal factors. Postnatal changes significantly alter the relationships between these key hormones.

Area of Science:

  • Endocrinology
  • Neonatal Physiology
  • Metabolic Research

Background:

  • Adipokines, such as leptin, adiponectin, and resistin, play crucial roles in metabolic regulation.
  • Understanding adipokine dynamics during the transition from fetal to neonatal life is essential for assessing early metabolic health.

Purpose of the Study:

  • To investigate the interrelationships among leptin, adiponectin, and resistin in fetal and early postnatal periods.
  • To examine the association of these adipokines with anthropometric and metabolic indices in newborns and their mothers.

Main Methods:

  • Serum concentrations of leptin, adiponectin, and resistin were measured in maternal and neonatal circulation.
  • Samples were collected at delivery and on the 3rd day postpartum from 40 healthy mother-newborn pairs.

Main Results:

  • Fetal leptin levels were significantly higher than in neonates on day 3 postpartum; adiponectin and resistin levels remained stable.
  • Leptin and adiponectin correlated in fetal circulation, while leptin and resistin correlated in neonatal circulation on day 3.
  • Fetal adipokine levels showed independence from maternal influences, with significant shifts in inter-adipokine relationships observed post-birth.

Conclusions:

  • Adipokine profiles undergo substantial changes immediately following birth, indicating a critical transition in metabolic regulation.
  • The distinct correlations observed between adipokines in fetal versus neonatal circulation highlight developmental adaptations.
  • These findings provide insights into the early programming of metabolic health and adipokine signaling pathways.

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