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Comparison of methods for evaluating drug-drug interaction

Liang Zhao1, Jessie L-S Au, M Guillaume Wientjes

  • 1College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.

Frontiers in Bioscience (Elite Edition)
|December 29, 2009
PubMed
Summary

Comparing drug-drug interaction analysis methods, this study found that curve shift, isobologram, combination index, and universal surface response analyses offer complementary insights into drug synergy and antagonism. Each method provides unique data for evaluating combination therapies.

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