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09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Poloxamine-based nanomaterials for drug delivery
Carmen Alvarez-Lorenzo1, Ana Rey-Rico, Alejandro Sosnik
1Dept Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782-Santiago de Compostela, Spain.
Frontiers in Bioscience (Elite Edition)
|December 29, 2009
Summary
Poloxamines, unique X-shaped polymers, form micelles for drug delivery, enhancing solubility and stability. These branched copolymers offer improved bioavailability and therapeutic effects for poorly soluble drugs.
Area of Science:
- Polymer Chemistry
- Materials Science
- Nanotechnology
Background:
- Poloxamines are X-shaped amphiphilic block copolymers with four PEO-PPO arms.
- Their structure provides multi-responsive behavior, including temperature and pH sensitivity.
- They form polymeric micelles above the critical micellar concentration (CMC).
Purpose of the Study:
- To review the applications of poloxamines in drug delivery.
- To highlight their role as micellar carriers for poorly water-soluble drugs.
- To discuss their use as surface modifiers for stealth nanoparticles.
Main Methods:
- Review of existing literature on poloxamine applications.
- Analysis of poloxamine self-assembly into micelles.
- Evaluation of chemical modification possibilities within the micellar core.
Main Results:
- Poloxamines effectively solubilize and stabilize poorly water-soluble drugs via micelle formation.
- They can be chemically modified for tailored drug delivery systems.
- Poloxamines serve as effective surface modifiers for stealth polymeric nanoparticles.
Conclusions:
- Poloxamines offer unique advantages over linear poloxamers in drug delivery.
- Their micellar properties enhance drug solubility, stability, and bioavailability.
- Further research into poloxamines holds significant potential for improved therapeutic outcomes.
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