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Related Experiment Video

Updated: Jun 17, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

Biomarkes of aging.

Sonya Vasto¹, Giovanni Scapagnini, Matteo Bulati

¹Department of Health Sciences, University of Molise, Campobasso, Italy. marcoc@unipa.it

Frontiers in Bioscience (Scholar Edition)

|December 29, 2009

Summary

Biological age, distinct from chronological age, varies individually. Disease-related biomarkers, focusing on immunosenescence, inflammation, and oxidative stress, aid in understanding ageing and developing anti-ageing strategies.

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Area of Science:

Gerontology and Cellular Biology
Biomarker Discovery
Aging Research

Background:

Aging is a complex process with variable rates among individuals due to genetic and environmental factors.
Biological age, reflecting functional decline, differs from chronological age and is a key area of research.
Identifying reliable biomarkers of aging is crucial for predicting disease risk and improving elderly quality of life.

Purpose of the Study:

To explore disease-related biomarkers for a better understanding of the aging process.
To discuss the utility of biomarkers related to immunosenescence, inflammatory responses, and oxidative stress in aging research.
To inform the development of anti-aging strategies to enhance healthspan and quality of life in the elderly.

Main Methods:

Focus on disease-related biomarkers rather than true biomarkers of aging.
Utilize data from author laboratories concerning immunosenescence, inflammatory responses, and oxidative stress.
Analyze age-related changes in body function and composition.

Main Results:

Current biomarkers are often disease-related, not true indicators of the aging process itself.
Immunosenescence, inflammation, and oxidative stress are key areas linked to aging.
Understanding these markers can help characterize biological age and identify individuals at risk for age-associated diseases.

Conclusions:

Disease-related biomarkers offer valuable insights into aging mechanisms, despite not being true biomarkers of aging.
Knowledge of immunosenescence, inflammation, and oxidative stress is essential for developing effective anti-aging interventions.
These strategies aim to slow aging, prevent diseases, and improve the well-being of the aging population.