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Related Experiment Video

Updated: Jun 17, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
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Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

Chemokine polymorphisms and lymphoma: a pooled analysis.

Paige M Bracci1, Christine F Skibola, Lucia Conde

  • 1Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94118-1944, USA. paige.bracci@ucsf.edu

Leukemia & Lymphoma
|December 30, 2009
PubMed
Summary

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Certain genetic variations in chemokine genes may influence the risk of non-Hodgkin lymphoma (NHL). The CCR5 Delta32 deletion, for example, appears to reduce NHL risk in men.

Area of Science:

  • Genetics
  • Immunology
  • Oncology

Background:

  • Polymorphisms in chemokine genes are linked to HIV-related lymphoma.
  • Their role in non-HIV-related lymphoma remains understudied.

Purpose of the Study:

  • To investigate associations between NHL and gene polymorphisms/haplotypes.
  • Focus on CCR5, CCR2, CCL5, CXCL12, and CX(3)CR(1) in HIV-negative individuals.

Main Methods:

  • Pooled analysis of three case-control studies (N=1610 cases, N=1992 controls).
  • Used adjusted unconditional logistic regression for risk estimation.
  • Analyzed HIV-negative, non-Hispanic Caucasian populations.

Main Results:

  • The CCR5 Delta32 deletion reduced NHL risk in men (OR=0.56), particularly for diffuse large-cell and follicular lymphoma (FL).

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Last Updated: Jun 17, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

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  • A CCR2/CCR5 haplotype with CCR5 Delta32 also reduced NHL risk in men.
  • The CCL5 -403A allele was associated with reduced risk of FL and chronic lymphocytic leukemia/small lymphocytic lymphoma.

    • Conclusions:

    • Specific chemokine gene polymorphisms may modify NHL risk in HIV-negative individuals.
    • Findings suggest a potential protective role for CCR5 Delta32 and CCL5 -403A in certain NHL subtypes, particularly in men.
    • Further research is needed to validate these associations.