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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws

Tong-Han Zhang1, Hai-Chao Liu, Gui-Qing Liao

  • 1Department of Oral and Maxillofacial Surgery, Sun Yat-Sen University, Guangzhou, China.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|December 31, 2009
PubMed
Abstract

Insights

Notch signaling plays a role in jaw bone development and cemento-ossifying fibroma (COF) growth. Aberrant Notch signaling may contribute to COF development, impacting cell differentiation and proliferation.

Area of Science:

  • Oral pathology
  • Molecular biology
  • Cell signaling

Background:

  • Cemento-ossifying fibroma (COF) is a benign jaw neoplasm.
  • The role of Notch signaling in COF oncogenesis and cytodifferentiation is not fully understood.

Purpose of the Study:

  • To investigate the expression and potential roles of Notch signaling pathway components in COF and normal jaw bone tissues.

Main Methods:

  • Reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry were used.
  • Detected expressions of Notch1, Notch3, Jagged1, and Jagged2.
  • Analyzed 12 COF cases and 16 normal jaw bone tissues.

Main Results:

  • Notch pathway components (Notch1, Notch3, Jagged1, Jagged2) were expressed in both COF and normal bone.
  • Higher mRNA expression levels of these components were observed in COF compared to normal bone.
  • Notch proteins were extensively distributed in COF fibroblasts and osteoblasts, with weaker expression in normal bone osteoblasts.

Conclusions:

  • Notch signaling is implicated in regulating cell differentiation and proliferation in both normal jaw bone and COF.
  • Disruptions in Notch signaling may be a key molecular event in the occurrence and progression of COF.

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