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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

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Published on: September 9, 2012

Asymptomatic factor VII deficiency: gene analysis and structure-function relationships.

Dean Kirkel1, Ta-Wei Lin, Sidney W Fu

  • 1Department of Medicine, Division of Hematology-Oncology, The George Washington University School of Medicine and Health Sciences and the Children's National Medical Center, Washington, District of Columbia 20037, USA.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|December 31, 2009
PubMed
Summary
This summary is machine-generated.

Factor VII Padua deficiency can cause prolonged prothrombin times with specific reagents. Identifying this benign condition prevents unnecessary treatments for factor VII deficiency.

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Last Updated: Jun 17, 2026

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Area of Science:

  • Hematology
  • Genetics

Background:

  • Factor VII deficiency is a rare bleeding disorder.
  • Factor VII Padua is a specific variant associated with prolonged prothrombin time (PT) using certain thromboplastins.

Observation:

  • A case of an asymptomatic African-American woman with factor VII deficiency is presented.
  • Her PT was prolonged with rabbit brain thromboplastin but normal with human, ox brain, or recombinant tissue factor reagents.

Findings:

  • The patient exhibited factor VII activity levels of 5-8% with rabbit brain thromboplastin.
  • Recombinant human thromboplastin assays revealed normal PT and factor VII activity.
  • The characteristic R304Q amino acid substitution of Factor VII Padua was identified.

Implications:

  • Accurate diagnostic methods are crucial for differentiating Factor VII Padua from other forms of factor VII deficiency.
  • Correct identification avoids unnecessary and potentially harmful treatments like plasma-derived products or recombinant activated factor VII.
  • This case highlights the importance of reagent selection in diagnosing factor VII variants.