Quantitative profiling and identification of outer membrane proteins of beta-lactam resistant strain of Acinetobacter
Jitendra Vashist1, Vishvanath Tiwari, Arti Kapil
1Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, 110029, India.
Abstract:
In the recent past, Acinetobacter baumannii in hospitals has become increasingly resistant to a number of antibiotics including the latest carbapenems and this is of great concern. Here, for the first time, we report 2D-Differential In-Gel Electrophoresis (DIGE) analysis of outer membrane proteome of ATCC 19606 and carbapenem-resistant strain of A. baumannii. Using biological variance analysis (BVA), we identified 25 differentially expressed proteins with a fold difference >or=2; confidence >90% and statistical significance p
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