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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

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Related Experiment Video

Updated: Jun 17, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Omega-3 and renal function in older adults.

F Lauretani1, M Maggio, F Pizzarelli

  • 1Geriatric Unit, Geriatric-Rehabilitation Department, University Hospital of Parma, Parma, Italy. flauretani@ao.pr.it

Current Pharmaceutical Design
|January 1, 2010
PubMed
Summary
This summary is machine-generated.

Higher intake of polyunsaturated fatty acids (PUFA) may protect against chronic kidney disease (CKD) progression. Low plasma PUFA levels in older adults were linked to a faster decline in kidney function over three years.

Related Experiment Videos

Last Updated: Jun 17, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Area of Science:

  • Nephrology
  • Nutritional Science
  • Epidemiology

Background:

  • Chronic kidney disease (CKD) is a significant global health issue, with increasing prevalence and incidence of end-stage renal disease.
  • Diabetes and hypertension are primary drivers of kidney damage, while infections and aging-related immune decline also contribute.
  • Oxidative stress, an imbalance between free radicals and antioxidants like polyunsaturated fatty acids (PUFA), is implicated in kidney pathology.

Purpose of the Study:

  • To investigate the association between plasma polyunsaturated fatty acid (PUFA) levels and the rate of decline in kidney function.
  • To determine if higher PUFA levels are protective against the progression of chronic kidney disease (CKD) in older adults.

Main Methods:

  • Analysis of total plasma PUFA levels and change in creatinine clearance over a three-year period.
  • Utilized data from the InCHIANTI study, a population-based epidemiological study in Tuscany, Italy.
  • Focused on an elderly cohort to assess long-term effects on renal function.

Main Results:

  • Older adults with lower plasma PUFA levels exhibited a more pronounced decrease in creatinine clearance over the three-year follow-up period.
  • This finding suggests a correlation between reduced PUFA levels and accelerated loss of kidney function.
  • Previous research indicated PUFA supplementation benefits IgA nephropathy and dialysis patients.

Conclusions:

  • Low levels of plasma polyunsaturated fatty acids (PUFA) are associated with a faster decline in kidney function in older adults.
  • Increased dietary intake of PUFA may play a protective role in preventing the progression of chronic kidney disease (CKD).
  • Further research into PUFA's role in renal health is warranted.