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Updated: Jun 17, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor

Zhiwei Wang1, Yiwei Li, Dejuan Kong

  • 1Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.

Current Drug Targets
|January 1, 2010
PubMed

Insights

The Notch signaling pathway influences cancer progression and epithelial-mesenchymal transition (EMT). Targeting Notch may reverse EMT, offering a new strategy for cancer prevention and treatment.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • The Notch signaling pathway regulates cell proliferation and apoptosis, crucial for development.
  • Its role in epithelial-mesenchymal transition (EMT) and cancer aggressiveness is not well understood.
  • Understanding Notch signaling in EMT is vital for cancer research.

Purpose of the Study:

  • To review the function of the Notch signaling pathway in EMT.
  • To catalog the involvement of Notch deregulation in EMT and tumor aggressiveness.
  • To summarize chemopreventive agents targeting Notch signaling for cancer treatment.

Main Methods:

  • Literature review of Notch signaling in EMT.
  • Analysis of studies on Notch deregulation and tumor aggressiveness.
  • Compilation of data on chemopreventive agents targeting Notch.

Main Results:

  • Notch signaling plays a significant role in EMT.
  • Deregulation of Notch signaling contributes to tumor aggressiveness.
  • Several chemopreventive agents show potential for Notch pathway inactivation.

Conclusions:

  • Notch signaling is implicated in EMT and cancer progression.
  • Targeted inactivation of Notch signaling may reverse EMT.
  • This approach presents a novel strategy for cancer prevention and treatment.

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