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Published on: April 28, 2016
The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides
Thomas A Knappe1, Uwe Linne, Xiulan Xie
1Department of Chemistry/Biochemistry, Philipps-University Marburg, Marburg, Germany.
Abstract:
The glucagon receptor antagonist BI-32169, recently isolated from Streptomyces sp., was described as a bicyclic peptide, although its primary structure comprises conserved elements of class I and class II lasso peptides. Tandem mass spectrometric and nuclear magnetic resonance spectroscopic studies revealed that BI-32169 is a lasso-structured peptide constituting the new class III of lasso peptides. The determined lasso fold opens new avenues to improve the promising biological activity of BI-32169.
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