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Can we identify a power-oriented polygenic profile?

Jonatan R Ruiz1, David Arteta, Amaya Buxens

  • 1Dept. of Biosciences and Nutrition at NOVUM, Unit for Preventive Nutrition, Karolinska Institutet, Huddinge 14157, Sweden. ruizj@ugr.es

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Summary
This summary is machine-generated.

Elite power athletes possess a distinct genetic profile, indicated by a higher total genotype score (TGS), compared to endurance athletes and controls. This genetic profile, involving six polymorphisms, helps differentiate power athletes and is rare in the general Spanish population.

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Area of Science:

  • Sports Science
  • Genetics
  • Human Physiology

Background:

  • Individual genetic variations influence athletic performance.
  • Specific polymorphisms are associated with power and endurance phenotypes.
  • Elite athletes often exhibit unique genetic profiles.

Purpose of the Study:

  • To determine the total genotype score (TGS) in elite power athletes, endurance athletes, and controls.
  • To identify the probability of Spanish individuals having an optimal power-oriented polygenic profile.
  • To differentiate elite power athletes based on a polygenic profile.

Main Methods:

  • Analysis of six candidate polymorphisms (ACE I/D, ACTN3 R577X, AGT Met235Thr, GDF-8 K153R, IL6 -174 G/C, NOS3 -786T>C).
  • Calculation of a total genotype score (TGS) based on accumulated polymorphisms.
  • Comparison of TGS across elite power athletes (n=53), elite endurance athletes (n=100), and nonathletic controls (n=100) (all Spanish Caucasian males).

Main Results:

  • Mean TGS was significantly higher in power athletes (70.8) compared to endurance athletes (60.4) and controls (63.3).
  • No significant difference in TGS was observed between endurance athletes and controls.
  • Five power athletes (9.4%), all sprinters, achieved an optimal TGS of 100; no individuals in other groups did.
  • The probability of a Spanish individual having the optimal polygenic profile for these six polymorphisms is approximately 0.2%.

Conclusions:

  • A specific polygenic profile can distinguish elite power athletes from endurance athletes and nonathletic individuals.
  • The genetic profile associated with elite power performance is uncommon in the general Spanish population.
  • This research contributes to understanding the genetic underpinnings of athletic specialization.