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Galectin-8 up-regulation during hypopharyngeal and laryngeal tumor progression and comparison with galectin-1, -3 and
Stéphanie Cludts1, Christine Decaestecker, Virginie Mahillon
1Laboratory of Anatomy, Faculty of Medicine and Pharmacy, University of Mons-Hainaut, Pentagone 1B - Avenue du Champ de Mars, 6, B-7000 Mons, Belgium.
Aim:
To define specific staining patterns for the adhesion/growth-regulatory lectin tandem-repeat-type galectin-8 in hypopharyngeal and laryngeal tumor progression and relate these parameters to galectins 1, 3 and 7 in the quest to explore the galectin network.
Materials And Methods:
The level of expression of galectin-8 was determined immunohistochemically in a series of 18 and 16 cases of tumor-free epithelium, 24 and 10 cases of low-grade dysplasia, 22 and 15 cases of high-grade dysplasia located in peri-tumoral area of 74 and 37 hypopharyngeal and laryngeal carcinomas.
Results:
Marked upregulation in galectin-8 staining intensity and immunopositive area in malignancy versus dysplasia was seen in hypopharyngeal cancer (p<10(-6)), in laryngeal cancer for labeling index and high-grade dysplasia/carcinoma (p<10(-6)). No correlation to recurrence was delineated.
Conclusion:
The presented data revealed a divergence within the galectin-1, -3, -7 and -8 network during tumor progression.
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