Related Experiment Video
Updated: Jun 17, 2026

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition
Published on: February 1, 2012
Insula and orbital frontal cortex activity underlying emotion interference resolution in working memory
Sara M Levens1, Elizabeth A Phelps
1Department of Psychology, Bldg. 420, Jordan Hall, Stanford University, Stanford, CA 94305, USA. slevens@stanford.edu
Abstract:
Previous research has shown that emotional information aids conflict resolution in working memory [WM; Levens, S. M., & Phelps, E. A. Emotion processing effects on interference resolution in working memory. Journal of Emotion, 8, 267-280, 2008]. Using a recency-probes WM paradigm, it was found that positive and negative emotional stimuli reduced the amount of interference created when information that was once relevant conflicted with currently relevant information. To explore the neural mechanisms behind these facilitation effects, an event-related fMRI version of the recency-probes task was conducted using neutral and arousing positive and negative words as stimuli. Results replicate previous findings showing that the left and right inferior frontal gyrus (IFG) is involved in the interference resolution of neutral information and reveal that the IFG is involved in the interference resolution of emotional information as well. In addition, ROIs in the right and left anterior insula and in the right orbital frontal cortex (OFC) were identified that appear to underlie emotional interference resolution in WM. We conclude that the IFG underlies neutral and emotional interference resolution, and that additional regions of the anterior insula and OFC may contribute to the facilitation of interference resolution for emotional information. These findings clarify the role of the insula and OFC in affective and executive processing, specifically in WM conflict resolution.
More Related Videos
09:14Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
10:33Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
Published on: June 20, 2012
Related Concept Videos
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Coping Strategies: Emotion Focused
Role of Cerebellum and Prefrontal Cortex in Memory
Working Memory
The Influence of Cognition on Affect
Functional Brain Systems: Limbic System