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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Mechanical Dissociation of Tissues for Single Cell Analysis Using a Motorized Device
05:06

Mechanical Dissociation of Tissues for Single Cell Analysis Using a Motorized Device

Published on: November 10, 2023

Enabling individualized therapy through nanotechnology.

Jason H Sakamoto1, Anne L van de Ven, Biana Godin

  • 1The University of Texas Health Science Center, Department of Nanomedicine and Biomedical Engineering, Houston, TX 77030, USA.

Pharmacological Research
|January 5, 2010
PubMed
Summary
This summary is machine-generated.

Individualized medicine leverages "-omic" technologies and nanotechnology for patient-specific therapies, moving beyond one-size-fits-all treatments. This approach enhances treatment efficacy by considering individual physiological differences.

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Mechanical Dissociation of Tissues for Single Cell Analysis Using a Motorized Device
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Area of Science:

  • Biotechnology and Nanomedicine
  • Genomics and Systems Biology

Background:

  • Standardized medicine often fails due to patient physiological idiosyncrasies.
  • The emergence of -omic technologies (genomics, proteomics, etc.) highlights the limitations of traditional therapeutic approaches.
  • Personalized medicine aims to replace generic treatments with patient-specific therapies.

Purpose of the Study:

  • To provide a forward-looking assessment of nanomedicine's potential in individualized medicine.
  • To present a snapshot of current nano-based products across various clinical indications.
  • To explore the integration of -omic technologies and systems biology for personalized healthcare.

Main Methods:

  • Analysis and integration of data from -omic technologies.
  • Leveraging systems biology approaches for clinical medicine.
  • Review of current nanotechnology applications in patient-specific therapy.

Main Results:

  • Nanotechnology is poised to play a crucial role in the advancement of patient-specific therapies.
  • A systems biology approach integrating -omic data is essential for clinical transition.
  • Current nano-based products show promise across diverse clinical indications.

Conclusions:

  • The transition to individualized medicine is dependent on technological advancements, particularly in nanotechnology and systems biology.
  • While non-scientific hurdles exist, scientific progress and healthcare demand will drive the adoption of personalized medicine.
  • Nanomedicine offers a promising pathway toward more effective, patient-specific healthcare solutions.