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  1. Home
  3. A High-throughput Modular Microfluidic Platform For Versatile Functional Assays At Single-cell Level.
  1. Home
  3. A High-throughput Modular Microfluidic Platform For Versatile Functional Assays At Single-cell Level.

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Related Experiment Video

A Microfluidic Platform for High-throughput Single-cell Isolation and Culture
09:51

A Microfluidic Platform for High-throughput Single-cell Isolation and Culture

Published on: June 16, 2016

A high-throughput modular microfluidic platform for versatile functional assays at single-cell level.

Ning Shao1, Junhua Mai2, Biana Godin2

  • 1Center for BioNanoengineering, Houston Methodist Research Institute, Houston, TX, USA. shaoning064@gmail.com.

Microsystems & Nanoengineering
|May 18, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

HiSCOPE, a new microfluidic platform, analyzes the functional dynamics of thousands of single cells, revealing hidden cellular diversity. This technology aids in understanding complex biology, disease, and advancing personalized medicine.

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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

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A Microfluidic Platform for High-throughput Single-cell Isolation and Culture
09:51

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Published on: June 16, 2016

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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Area of Science:

  • Single-cell biology
  • Microfluidics
  • Functional genomics

Background:

  • Current single-cell technologies offer limited functional insights, providing only static molecular data.
  • Understanding dynamic cellular behavior is crucial for deciphering biological complexity and disease mechanisms.

Purpose of the Study:

  • To introduce the High-throughput Single-Cell Omni-functional Profiling Engine (HiSCOPE) for dynamic single-cell functional profiling.
  • To demonstrate HiSCOPE's capability in analyzing diverse cellular functions and interactions.

Main Methods:

  • Development of a microfluidic platform (HiSCOPE) with hydrodynamic trapping for single cells, pairs, and trios.
  • Integration of modular assay chambers to support various functional assays (viability, proliferation, cytotoxicity, cytokine secretion, cell-cell interactions).
  • Incorporation of live-cell retrieval for downstream molecular analysis.

Main Results:

  • HiSCOPE successfully profiled functional dynamics of over 10,000 single cells.
  • Demonstrated utility in evaluating drug susceptibility in leukemia cells and NK cell cytotoxicity.
  • Dissected T cell-macrophage crosstalk, revealing functional diversity masked in bulk assays.

Conclusions:

  • HiSCOPE provides a scalable solution for high-throughput functional profiling of single cells.
  • The platform enables deeper understanding of cellular heterogeneity and interactions.
  • HiSCOPE has broad implications for advancing immunotherapy and personalized medicine.